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Hyperbaric oxygen therapy for burns & thermal injury

Explore additional support for burn healing. Research describes promising wound-healing and tissue-recovery findings when hyperbaric oxygen therapy is added to appropriate burn care. An RX-O2 consultation can help you and your treating clinician explore whether HBOT fits your recovery plan.1, 3

Consultations are for medically stable patients with an established care plan. Acute severe burns may require HBOT within a specialized burn-center setting.

An RX-O2 team member checking a patient's blood pressure beside an open hyperbaric chamber
Personal attention, before treatment.Start with questions. Build a plan with your care team.
Patient preparation at RX-O2.
FDA-cleared chambersHard-shell hyperbaric systems
100% medical oxygenBreathed through a dedicated mask or hood
Physician-led careMedical evaluation before treatment
NHSA-certified techniciansAttentive monitoring throughout your visit

Oxygen and the healing process

Helping injured tissue move toward recovery

Thermal injuries include burns from flames, hot surfaces, hot liquids, and steam. Injured tissue can have reduced circulation and oxygen availability. HBOT increases oxygen delivery and is studied as a way to support healing alongside dressings, appropriate surgery, infection treatment, and rehabilitation.14

01 / Wound healing

Support for skin repair

A prospective study of deep second-degree burns reported faster wound epithelialization—the formation of a new skin surface—with additional HBOT. This offers a reason to discuss its role in a selected treatment plan.3

02 / Tissue preservation

Potential to reduce surgical needs

Some clinical studies report fewer operations or grafts. These findings are encouraging, while burn depth and tissue viability still determine whether surgery is needed.1, 3

03 / Healing environment

Addressing swelling and low oxygen

Hyperbaric research explores improved tissue oxygenation, reduced edema, and support for infection-control mechanisms. Clinical benefit depends on the injury and the complete care plan.11, 14

You do not need all the answers before contacting us. Bring your questions, your current care plan, and what you hope to understand. A consultation can help you weigh potential benefits, uncertainty, practical needs, and costs before making a treatment decision.

Evidence that informs the conversation

The research behind HBOT and burn healing

Start with recent clinical findings, then explore the supporting studies below. Burn severity, treatment timing, and study design all influence what the results can tell us.

Literature checked
September 11, 2026

Systematic review · 2026

Promising healing findings across the clinical literature

13 included studies · mixed clinical designs

A review in the Journal of Burn Care & Research found encouraging signals for wound healing, infection control, and reduced surgical needs in selected studies. Some studies also reported shorter hospital stays.

Results were inconsistent across populations and protocols, preventing a meaningful pooled analysis. A survival benefit is not established. The authors support considering HBOT for selected patients in burn centers while calling for stronger trials.

Read the 2026 systematic review

Clinical case series · 2025

Recent experience with thermal-burn recovery

82 patients · retrospective and prospective observations

At the Vietnam National Institute of Maritime Medicine, clinicians reported favorable recovery observations in people receiving HBOT for thermal burns. Most injuries involved less than 10% of body surface area, and the authors reported hospital stays shorter than their expected figures.

This was an uncontrolled series, not a randomized comparison. Expected hospital stays are not a concurrent control group, and the observations do not establish how much improvement came from HBOT. A published correction accompanies the article.

Read the 2025 clinical series Published correction

Prospective observational study · 2023

Faster skin closure and fewer grafting procedures

38 patients completing the study · deep second-degree burns

Adding HBOT to conventional care was associated with significantly faster epithelialization and lower requirements for surgery and grafting. These outcomes address practical priorities for burn recovery.

Treatment was not randomized. Differences in hospital stay and cost did not reach statistical significance, despite favorable numerical trends. The findings do not promise that an individual can avoid grafting.

Read the deep second-degree burn study

Timing and treatment setting matter

European hyperbaric consensus guidance supports selected adjunctive use for burns, with level C evidence. It also recommends specialized hyperbaric centers close to burn services, with appropriate monitoring and fluid management. Acute thermal burns are addressed in a dedicated hyperbaric indications chapter.13, 14, 16

For an acute serious burn, ask your hospital team about timely hyperbaric assessment. A later outpatient consultation has a different purpose: reviewing your current recovery needs and whether additional care is appropriate.

Look more closely

Additional clinical studies and research context

2026 case report: a complex burn wound with resistant infection

A patient with persistent infection and delayed healing improved during care that combined HBOT, repeated debridement, targeted antibiotics, and rehabilitation. The report describes wound closure and functional recovery in a challenging setting. One case cannot separate HBOT’s contribution from the other treatments or predict a recovery timeline. Read the case report.

2021 small controlled study: complications and inflammatory markers

A 20-patient study reported fewer thermal-wound complications, shorter hospital stays, and reductions in the inflammatory marker ICAM-1 with adjunctive HBOT. Although the methods describe random allocation, the paper is titled a case-control study and provides limited allocation detail. The difference in complete epithelialization was not statistically significant. Read the clinical study.

2017 hospital cohort: recovery after a mass-casualty burn event

Among 53 people treated after the Taiwan Formosa Water Park disaster, the 38 receiving HBOT had faster normalization of procalcitonin, a marker used in assessing infection and systemic inflammation. All patients survived in both groups. This retrospective comparison supports further investigation of adjunctive care; it does not establish a survival benefit or show that HBOT replaces infection treatment. Read the hospital cohort.

2015 human experiment: sensitivity after a controlled thermal injury

A randomized crossover experiment in 17 healthy volunteers found reduced areas of heightened pain sensitivity overall after HBOT. Results differed by treatment sequence. These were small experimental first-degree injuries, not patients recovering from major burns; the findings cannot establish relief of chronic burn pain. Read the human experimental study.

2024 review: why the treatment protocol matters

A review of animal work, volunteer experiments, and clinical studies found predominantly favorable but variable results. Its analysis linked treatment pressure to study outcomes. Because the evidence combines very different models and designs, it supports protocol research rather than a universal pressure or treatment schedule for patients. Read the protocol-focused review.

Foundational randomized evidence: the Cochrane review

The 2004 Cochrane review identified two eligible randomized trials of poor methodological quality. One reported faster healing, while another found no difference in key outcomes after adjustment. The reviewers found insufficient evidence to confirm or rule out effectiveness. This older review helps explain why promising findings still need stronger confirmation. Read the Cochrane review.

Developing science

Laboratory findings that help explain the possibilities

These are animal experiments. They investigate mechanisms and cannot establish outcomes or treatment settings for people.

Rabbit experiment · 2022

Bacterial growth

A controlled burn model found less bacterial growth with HBOT, supporting investigation of infection-related mechanisms. It does not show that HBOT alone clears a human burn infection.

Read the bacterial-growth study

Rabbit experiment · 2019

New skin formation

Researchers observed improved epithelialization and changes in inflammatory-cell activity. Angiogenesis did not differ significantly, so this experiment does not establish increased blood-vessel growth.

Read the wound-healing study

Rat experiment · 2019

Burn-related pain pathways

HBOT reduced mechanical pain sensitivity in a burn model, with changes in several signaling pathways. Human studies are needed to determine whether these findings translate into lasting pain relief.

Read the pain-pathway study

Find newer burn and HBOT research on PubMed. Results are sorted by publication date; new results have not necessarily been assessed for this page. Studies may appear in more than one review and should not be counted as additional independent evidence.

Your recovery, your next step

Bring your burn-care plan to the conversation

If you are medically stable, a consultation can explore whether hyperbaric treatment might complement your current wound or recovery care. Bring information that helps the evaluating provider understand the injury and coordinate with your treating clinician.

  • Date and cause of the burn
  • Burn depth and wound reports
  • Grafting or surgical history
  • Dressings, medicines, and care plan

We can discuss your goals, current healing progress, relevant research, practical needs, and cost. Medical review determines whether HBOT is appropriate and whether RX-O2 can provide the level of care you need.

Already receiving hospital burn care? Ask your inpatient team about hyperbaric options. Continue prescribed wound care and rehabilitation; do not delay surgery, infection treatment, or hospital care for an outpatient visit.

Call RX-O2 about a coordinated consultation

The RX-O2 difference

Your facility matters. So does your team.

From your first questions to each treatment visit, our Scottsdale and Glendale clinics focus on medical oversight, patient education, and attentive care.

Blood-pressure check beside open hyperbaric chambers in the RX-O2 Scottsdale clinic

Care led by a physician

Medical Director Marvin A. Borsand, DO, FACOS, FACCS, HCC, leads clinical oversight. A licensed medical provider evaluates suitability and prescribes treatment when appropriate.

FDA-cleared hard-shell chambers

Our facilities use prescription-level hyperbaric systems, with chamber selection and treatment settings matched to your prescribed plan.

100% medical-grade oxygen

You breathe oxygen through a dedicated mask or hood while the chamber is pressurized with air. Your technicians monitor you throughout treatment.

NHSA-certified hyperbaric technicians

Our technicians are certified through the National Hyperbaric Safety Association and trained in chamber operations, patient monitoring, and emergency procedures.

Meet the RX-O2 team

A practical path forward

Start with a consultation. Plan from there.

  1. Share your care plan

    Tell us where you are in recovery and who is managing your burn. Confirm with your treating clinician that an outpatient consultation is appropriate.

  2. Review the fit

    Discuss the research, your wound status, medical history, and any monitoring or mobility needs. A licensed medical provider evaluates suitability.

  3. Coordinate next steps

    If HBOT is recommended in an appropriate setting, plan the prescription, follow-up, visits, and costs alongside your existing care.

Consult before purchasing a treatment package. Explore our current pricing and packages, then confirm the recommended care plan and treatment setting with the team.

Local care, two Valley locations

Explore HBOT in Scottsdale or Glendale

Looking for a hyperbaric consultation near Phoenix? RX-O2 offers two locations for patients across the Valley. Call the clinic closest to you for appointment availability and help planning repeat visits.

Questions are welcome

Questions about HBOT for burns

A helpful conversation begins with your current needs and recovery goals.

Can HBOT help a burn heal?

It may offer additional support in selected cases. Clinical research describes faster skin closure and fewer surgical procedures in some studies. The evidence remains variable, so the decision should be individualized with your burn-care and hyperbaric clinicians.1, 3

Should I come to RX-O2 immediately after a serious burn?

A serious new burn needs emergency assessment and potentially burn-center care. RX-O2 consultations do not replace those services. If acute HBOT is being considered, your hospital team should arrange an appropriate service with the necessary monitoring and support.13, 17

Can HBOT replace grafting, antibiotics, or wound care?

No. HBOT is an adjunct. Continue prescribed dressings, indicated surgery, infection treatment, and rehabilitation. An encouraging research result is a reason for a specialist discussion, not a reason to postpone necessary care.

What if my burn is older or healing slowly?

Contact us to discuss a review with your treating clinician. Delayed healing, infection, and graft problems require their own assessment. Much of the burn literature concerns acute injuries; a 2026 case report of a complex non-healing burn offers preliminary context but does not establish routine HBOT for all older burns.6

Can HBOT remove burn scars or prevent all scarring?

Research on wound healing should not be interpreted as proof that HBOT removes established scars or guarantees scar prevention. Your clinician can assess scar treatment and rehabilitation needs separately from an active wound-healing plan.

How many visits will I need, and what does it cost?

There is no universal course for every burn. Timing, wound status, medical needs, and treatment setting influence the recommendation. Review pricing and packages and discuss suitability before purchasing. Published research or a listed package does not guarantee insurance coverage.

What should I know about chambers, oxygen, and safety?

RX-O2 uses FDA-cleared hard-shell chambers with physician-led care and NHSA-certified technicians. You breathe 100% medical oxygen through a dedicated mask or hood in an air-pressurized chamber. Discuss lung and ear conditions, medicines, dressings, and devices before treatment. Possible risks include ear-pressure injury, temporary vision changes, and confinement anxiety; less common serious risks include oxygen-induced seizures and lung pressure injury. Staff must review dressings and materials for chamber compatibility. Electronics and battery-powered devices are not allowed inside chambers.19, 20

Where can I book a consultation near Phoenix?

Contact RX-O2 in Scottsdale at 480-270-6090 or Glendale at 623-930-0887. For an appropriate non-emergency consultation, you can also book online. Booking is a consultation request; medical review determines treatment suitability.

Let’s talk about your next step in recovery.

Bring your questions and current care plan to an RX-O2 consultation in Scottsdale or Glendale.

Sources & further reading

  1. Molina-Vega J et al. (2026). Hyperbaric Oxygen Therapy in Burn Care: A Systematic Review of Current Evidence. J Burn Care Res.
  2. Pham LH et al. (2025). Initial results of treating thermal burns by hyperbaric oxygen at the Vietnam National Institute of Maritime Medicine. Int Marit Health.
  3. Özdemir Ü et al. (2023). Effects of hyperbaric oxygen therapy on clinical and economic outcomes in patients with deep second-degree burns. Undersea Hyperb Med.
  4. Oley MH et al. (2021). Effects of hyperbaric oxygen therapy on the healing of thermal burns and its relationship with ICAM-1: A case-control study. Ann Med Surg (Lond).
  5. Chiang IH et al. (2017). Adjunctive hyperbaric oxygen therapy in severe burns: Experience in Taiwan Formosa Water Park dust explosion disaster. Burns.
  6. Oley MH et al. (2026). Adjunctive hyperbaric oxygen therapy for chronic burn injuries complicated by MRSA and multidrug-resistant infections: a case report. Int J Surg Case Rep.
  7. Rasmussen VM et al. (2015). Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans. Acta Anaesthesiol Scand.
  8. Oley MH et al. (2022). Bactericidal effect of hyperbaric oxygen therapy in burn injuries. Ann Med Surg (Lond).
  9. Hatibie MJ et al. (2019). Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study in Rabbits. Adv Skin Wound Care.
  10. Wu ZS et al. (2019). Dose-Dependent Effect of Hyperbaric Oxygen Treatment on Burn-Induced Neuropathic Pain in Rats. Int J Mol Sci.
  11. Smolle C et al. (2024). Hyperbaric oxygen (HBO2) therapy in thermal burn injury revisited. Pressure does matter. Review. Undersea Hyperb Med.
  12. Villanueva E et al. (2004). Hyperbaric oxygen therapy for thermal burns. Cochrane Database Syst Rev.
  13. Mathieu D et al. (2017). Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med.
  14. Cianci P et al. (2026). Adjunctive Hyperbaric Oxygen in the Treatment of Thermal Burns. Undersea Hyperb Med.
  15. Pham LH et al. (2025). ERRATUM: Initial results of treating thermal burns by hyperbaric oxygen at the Vietnam National Institute of Maritime Medicine. Int Marit Health.
  16. Mathieu D et al. (2017). Correction to Mathieu D, Marroni A, Kot J: Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med. 2017 Mar;47(1):24-32. Diving Hyperb Med.
  17. American Burn Association. Guidelines for Burn Patient Referral.
  18. NHS (2026). Burns and scalds. Reviewed March 31, 2026.
  19. FDA (2025). Follow Instructions for Safe Use of Hyperbaric Oxygen Therapy Devices.
  20. Heyboer M III et al. (2017). Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified. Advances in Wound Care, 6(6), 210–224.

This page discusses twelve selected research publications: six human clinical reports or experiments, three animal experiments, and three evidence reviews. Guidance, corrections, and safety sources complete the references. Studies included in reviews are not additional independent patient groups.

Literature checked September 11, 2026. This is a source-check date, not an independent physician-review attestation or an exhaustive systematic review. These summaries are educational; a clinical evaluation is needed to discuss individual suitability.