# RX-O2: Anoxic and hypoxic brain injury

> Companion to the patient page and its cited research.

Page: https://rx-o2.com/pages/hyperbaric-oxygen-therapy-anoxic-hypoxic-brain-injury
Research hub: https://rx-o2.com/pages/hbot-research#condition-anoxic-injury
Literature checked: 2026-09-10. This is a source-check date, not an independent physician-review attestation.

## Clinical context
HBOT for recovery after anoxic or hypoxic brain injury is an emerging, off-label adjunct. Small clinical reports describe encouraging cognitive, consciousness-scale, or functional changes, with important uncertainty from nonrandomized designs and combined treatment. A cardiac-arrest series reported significant global and executive-function changes; its full-text memory and attention results did not meet the usual statistical threshold despite the abstract wording. A single drowning case cannot establish a general treatment effect. Newborn studies, animal experiments, and a 2025 preprint are labeled separately on the page.

These findings do not establish reversal of permanent brain injury or reliable restoration of consciousness. No universal session count or treatment window is established. Continue neurological, cardiac, and rehabilitation care. Outpatient consultation follows medical stabilization. Patients needing ventilation or intensive support require a hospital team to determine the appropriate setting. For new collapse, drowning, trouble breathing, or sudden neurological change, call 911.

## RX-O2 facilities
Physician-led care using FDA-cleared hard-shell chambers. Patients breathe 100% medical-grade oxygen through a dedicated mask or hood while the chamber is pressurized with air. Equipment clearance does not establish approval for this brain-injury indication. Technicians are certified through the National Hyperbaric Safety Association (NHSA).
Medical Director: Marvin A. Borsand, DO, FACOS, FACCS, HCC.
Electronics and battery-powered devices are not allowed inside chambers. Medical clearance, a prescription, and assessment of mobility, communication, and caregiver needs precede treatment.

Scottsdale: 9035 E Pima Center Parkway #11, Scottsdale, AZ 85258. Phone: +1-480-270-6090.
Glendale: 5626 N 51st Avenue, Glendale, AZ 85301. Phone: +1-623-930-0887.

## Appointments and information
- [Book a consultation](https://rx-o2.janeapp.com/)
- [Pricing and package purchases](https://rx-o2.com/pages/pricing-packages)
- [Scottsdale clinic](https://rx-o2.com/pages/hyperbaric-oxygen-therapy-scottsdale-az)
- [Glendale clinic](https://rx-o2.com/pages/hyperbaric-oxygen-therapy-glendale-az)
- [Find newer indexed research](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22Hyperbaric+Oxygenation%22%5BMeSH+Terms%5D+OR+%22hyperbaric+oxygen%22%5BTitle%2FAbstract%5D%29+AND+%28%22anoxic+brain%22%5BTitle%2FAbstract%5D+OR+%22hypoxic+brain%22%5BTitle%2FAbstract%5D+OR+%22hypoxic+ischemic%22%5BTitle%2FAbstract%5D+OR+%22hypoxic-ischemic%22%5BTitle%2FAbstract%5D+OR+%22cardiac+arrest%22%5BTitle%2FAbstract%5D+OR+drowning%5BTitle%2FAbstract%5D%29&sort=pubdate)

## Selected research
- Hadanny A et al. (2015). Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci. https://pubmed.ncbi.nlm.nih.gov/26409406/
- Sankaran R et al. (2019). Hyperbaric oxygen therapy in patients with hypoxic ischemic encephalopathy. Neurol India. https://pubmed.ncbi.nlm.nih.gov/31347544/
- Ribeiro AF et al. (2021). Hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy in non-fatal drowning. Undersea Hyperb Med. https://pubmed.ncbi.nlm.nih.gov/33648033/
- Harch PG, Fogarty EF. (2017). Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal of brain volume loss: a case report. Med Gas Res. https://pubmed.ncbi.nlm.nih.gov/28744368/
- Gong XB et al. (2022). Efficacy and Prognosis of Hyperbaric Oxygen as Adjuvant Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-Analysis Study. Front Pediatr. https://pubmed.ncbi.nlm.nih.gov/35529335/
- Xue R et al. (2023). Effect of Hyperbaric oxygen on myelin injury and repair after hypoxic-ischemic brain damage in adult rat. Neurosci Lett. https://pubmed.ncbi.nlm.nih.gov/36526030/
- Mielecki D et al. (2024). Hyperbaric oxygen therapy for the treatment of hypoxic/ischemic injury upon perinatal asphyxia-are we there yet?. Front Neurol. https://pubmed.ncbi.nlm.nih.gov/38685945/
- Huang Y et al. (2026). Neuroprotective Mechanisms of Hyperbaric Oxygen Therapy in Cerebral Ischemia-Hypoxia Injury Following Cardiopulmonary Resuscitation. Int J Med Sci. https://pubmed.ncbi.nlm.nih.gov/41583503/
- Schnaubelt S et al. (2025). Hyperbaric oxygen therapy in patients after cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A randomized controlled trial  (HOT-RESUS 1 study). medRxiv preprint, not peer reviewed in this version. https://doi.org/10.1101/2025.11.24.25340933